Biotin and derivatives
Medchemexpress LLC Bis-biotin-PEG23 | 293298-36-9 | 97.8% | C68H128N6O27S2 | 10MG
Bis-Biotin-PEG23 is a polyethylene glycol (PEG)-based PROTAC linker bearing biotin groups at both termini, designed to facilitate the assembly of bifunctional molecules and to introduce biotin affinity tags for pull-down or detection assays. It is supplied as a solid with high specified purity and is intended for research applications requiring a hydrophilic, flexible spacer.
- Two terminal biotin groups for affinity capture and detection.
- Long PEG23 spacer provides flexibility and improved solubility.
- High purity suitable for analytical and synthetic workflows.
- Solid form allows convenient handling and storage.
- Storage under low temperature and inert atmosphere preserves stability.
Medchemexpress LLC Sulfo-NHS-Acetate sodium | 221222-61-3 | 95.0% | C6H6NNaO7S | 50 MG
Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
- Alkyl chain-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs degrade target proteins by exploiting the intracellular ubiquitin-proteasome system.
Medchemexpress LLC Azido-PEG5-NHS ester | 1433996-86-1 | ≥98.0% | C17H28N4O9 | 50 MG
Azido-PEG5-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent due to its azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. It also facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups, leveraging the ubiquitin-proteasome system for selective protein degradation.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables targeted protein degradation
Medchemexpress LLC M-PEG13-NHS ester | 3063847-98-0 | 95.0% | C32H59NO17 | 50 MG
M-PEG13-NHS ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Can be used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Biotin-PEG2-NH-Boc | 175885-18-4 | C21H38N4O6S | 100 MG
Biotin-PEG2-NH-Boc is a biotin-labeled, PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It is intended for research purposes only. PROTACs function by utilizing the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins, achieved through two different ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other the protein of interest.
- PROTAC linker
- Useful in cancer research and targeted therapy
Medchemexpress LLC Boc-N-PEG1-C2-NHS ester | 1260092-55-4 | 97.0% | C14H22N2O7 | 1 G
Boc-N-PEG1-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DBCO-NHCO-S-S-NHS ester | 96.0% | 565.66 | C28H27N3O6S2 | 25 MG
DBCO-NHCO-S-S-NHS ester is a cleavable antibody-drug conjugate (ADC) linker and click-chemistry reagent containing a DBCO moiety. It is designed to couple to amines via the NHS ester and to react with azide-bearing molecules through strain-promoted alkyne-azide cycloaddition (SPAAC); the disulfide (S-S) bond provides a reducible, cleavable linker for payload release.
- cleavable disulfide linker for reductive release
- n-hydroxysuccinimide (nhs) ester for amine coupling
- dbco group enables copper-free spaac click chemistry with azides
- solid, white to off-white appearance for easy handling
- available in small research pack sizes (including 25 mg)
- storage: powder at -20°C; in solvent stability at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC NOTA-NHS ester | 1338231-09-6 | MFCD30747764 | ≥97.0% | 400.38 g/mol | C16H24N4O8 | 25 MG
NOTA-NHS ester is a bifunctional chelator derivative used for fluorescent labeling and radiolabeling (radionuclide-drug conjugates). It contains an activated N-hydroxysuccinimide (NHS) ester for conjugation to primary amines and a NOTA chelator for radiometal coordination. Supplied for research use only.
- Activated N-hydroxysuccinimide (NHS) ester for conjugation to primary amines.
- NOTA chelator for stable binding of radiometals.
- Purity ≥97.0%.
- CAS number 1338231-09-6.
- Molecular formula C16H24N4O8; molecular weight 400.38 g/mol.
- Recommended storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC Biotin-PFP ester | 120550-35-8 | 97.0% | 250 MG
Biotin-PFP ester is a pentafluorophenyl-activated biotin reagent for bioconjugation and linker chemistry. The activated ester reacts efficiently with primary amines to form stable amide bonds, enabling biotin tagging for affinity capture, detection, and proteomics workflows. Supplied as a research-grade solid suitable for small-scale synthesis.
- Activated pentafluorophenyl ester for efficient amide coupling
- Provides a biotin tag for affinity purification and detection
- Compatible with conjugation to primary amines under mild conditions
- High purity for reproducible synthetic and proteomics results
- Packaged for research-scale use and storage
Medchemexpress LLC Azido-PEG3-O-NHS ester | 2110448-98-9 | 95% | C13H20N4O8 | 100 MG
Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. This click chemistry reagent features an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN group-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
eMolecules 2280998-74-3 | Medchem Express | m-PEG11-acid | 50mg | 721309591 | HY-140501 | MFCD27977512 | 544.635 | C24H48O13
Ambeed | 2-(4-Carbamimidoylphenyl)acetic acid hydrochloride | 100mg | 490510431 | A142490 | 52798-09-1 | MFCD11505975 | 214.650 | C9H11ClN2O2
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Medchemexpress LLC Biotin-PEG4-OH | 1217609-84-1 | 98.0% | 25 MG
Biotin-PEG4-OH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one ligand binding to an E3 ubiquitin ligase and the other to the target protein. These molecules leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. It has a molecular weight of 419.54 and an appearance of a white to off-white solid. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight: 419.54
- Appearance: white to off-white solid
- For research use only
Medchemexpress LLC L-biotin | 21788-37-4 | 99.7% | 244.31 g/mol | C10H16N2O3S | 50 MG
L-biotin is the unnatural enantiomer of biotin supplied as a high-purity research reagent for laboratory use (not for human or clinical applications).
- High purity (reported 99.5-99.7%).
- Cas number 21788-37-4.
- Molecular weight 244.31 g/mol.
- Chemical formula C10H16N2O3S.
- Available in small milligram quantities such as 50 MG.
Medchemexpress LLC Sulfo-Cy3-NHS disodium | 865.90 g/mol | C36H41N3Na2O13S3 | 10 MG
Sulfo-Cy3-NHS disodium is a water-soluble Cyanine3 (Cy3) derivative bearing an NHS ester for amine-reactive conjugation. The sulfonate groups increase aqueous solubility, making this reagent suitable for labeling proteins, peptides, and antibodies for fluorescence detection and imaging.
- Water-soluble NHS ester for efficient labeling of primary amines.
- Improved aqueous solubility due to sulfonate groups.
- Suitable for conjugation to proteins, antibodies, and peptides.
- Enables fluorescence detection and imaging applications.
- Stable solid form for routine laboratory handling and storage per manufacturer instructions.
Medchemexpress LLC IL-13 Human Biotin 100ug
IL-13 protein is a cytokine involved in allergic inflammation immune response to parasites and B cell proliferation IL-13 Protein Human (Biotinylated HEK293 Avi-His) is the recombinant human-derived IL-13 protein expressed by HEK293 with C-Avi C-6 His labeled tag